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KMID : 0614020030180010026
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Journal of Pharmaceutical Sciences (C.N.U.)
2003 Volume.18 No. 1 p.26 ~ p.31
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Screening on NFAT transcription factor inhibitors from natural products
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Lee Im-Seon
Nguyen Tien-Dat
Cai Xing-Fu
Shen Guang-Hai
Kim Young-Ho
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Abstract
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The NFAT (nuclear factor of activatied T cells) protein induces transcription of genes required for T-cell activation, including the L - 2 gene. Activation of NFAT normally plays a significant role in inducing immune response. However, excessive activation provokes immunopathological reactions including autoimmunity, transplant rejection and inflammation. Thus, one hundred of natural products were screened on the inhibitory activity against the NFAT transcription factor. Three natural products (Celtis choseniana, Acer tegmentosum, Rubus takesimensis) showed strong inhibitory activity against the NFAT transcription factor without affecting cell viability. These MeOH extracts will be successively partitioned with CHCl₃, BuOH and H₂O to isolate active compound for the development of anti-inflammatory or immunosuppressive agent with good safety.
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KEYWORD
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NFAT transcription factor, natural products, Celtis choseniana, Acer tegmentosum, Rubus takesimensis
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